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Implementing a Bivariate Continual Reassessment Method in a Non-Oncology First In Human Trial
Speaker: Dr Alun Bedding, Roche Pharmaceuticals

Chair: Professor Adrian Mander, Cardiff University

Abstract:
This talk will look at the application of a bivariate CRM model in a first in human trial in a treatment with potential severe side effects. It will step through the process with the trial and will highlight how the CRM was used to inform decisions. The talk will also highlight the sorts of things that can go wrong and will suggest ways for these to be mitigated.

This event is part of the NIHR Statistics – Early Phase Trials Group webinar series on “Implementing a Bivariate CRM in a Non-Oncology First In Human Trial”. Registration is free and is limited to 100 attendees. Places will be offered on a first come first served basis. A recording of the webinar will be made available after the event.

For further information, please contact Professor Christina Yap, christina.yap@icr.ac.uk (webinar organiser and co-chair of the NIHR Statistics Group – Early Phase Clinical Trials) and Ms Tara Thorneycroft, tara.thorneycroft@icr.ac.uk (event co-ordinator).

Data Protection Act: Contact details will be held on a database at the ICR-CTSU (Clinical Trials and Statistics Unit) for purposes related to the webinar only.

Jul 29, 2020 03:00 PM in London

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Speakers

Dr Alun Bedding
Head of Methods, Collaboration and Outreach @Roche Pharmaceuticals
Alun Bedding is currently the Head of Methods, Collaboration and Outreach in the Biostatistics department at Roche/Genentech. He has worked in the pharmaceutical industry for over 30 years and specializes in early clinical development, most specifically dose finding, dose escalation, adaptive trials and Bayesian methods. He is a member of the DIA Adaptive Design Working Group and has contributed to many of their publications. He is also on the board of directors for the R Consortium and is a former member of the MRC Developmental Pathway Funding Scheme panel. Alun has a PhD from the University of Reading.