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CONCORDE: a phase I platform trial using the TiTE-CRM design
Speaker: Dr Sarah Brown, Associate Professor of Early Phase Clinical Trials, University of Leeds

Chair: Professor Christina Yap, Professor of Clinical Trials Biostatistics, The Institute of Cancer Research

Abstract: CONCORDE is a phase I platform trial, designed to determine the recommended phase II doses (RP2Ds) of 5 DNA damage repair inhibitors in combination with radiotherapy, for patients with lung cancer. To account for long-term toxicity associated with radiotherapy, we apply the time-to-event continuous reassessment method to facilitate dose escalation and determine RP2Ds. Weighting is given to short- and long-term DLT periods in the TiTE-CRM model. A calibration cohort of patients treated with radiotherapy alone acts as a control group pooled across the platform to aid interpretation of toxicity and DLT attribution.

This event is part of the NIHR Statistics – Early Phase Trials Group webinar series on ““Practical applications of advanced designs in Phase I Trials”. Registration is free and is limited to 100 attendees. Places will be offered on a first come first served basis. A recording of the webinar will be made available after the event.

For further information, please contact Professor Christina Yap, christina.yap@icr.ac.uk (webinar organiser and co-lead of the NIHR Statistics Group – Early Phase Clinical Trials) and Ms Tara Thorneycroft, tara.thorneycroft@icr.ac.uk (event co-ordinator).

Data Protection Act: Contact details will be held on a database at the ICR-CTSU (Clinical Trials and Statistics Unit) for purposes related to the webinar only.

Oct 28, 2020 03:00 PM in London

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Dr Sarah Brown
Associate Professor of Early Phase Clinical Trials @University of Leeds